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We describe a patient with inherited plasminogen deficiency who developed extensive cerebral venous thrombosis. Herein we present a case of life-threatening necrotizing pancreatitis, which developed in a hyperlipidemic pregnant woman and required multiple peripartum pancreatic necrosectomies. Venous thromboembolism is frequently associated with hormonal factors in women. Bone metastases are a frequent and devastating complication in cancer patients.

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